Potential Future Pharmacological Treatment of Bladder Dysfunction
نویسندگان
چکیده
منابع مشابه
Pharmacological Treatment of Bladder Dysfunction
Above ureteric orifices 3 layers – adventitia, smooth muscle, and urothelium. Haphazard arrangement of smooth muscle myofibrils. Acts as functional syncytium. No specific gap junctions, but ‘areas of close proximity’ 2 main populations of receptors, cholinergic (muscarinic) and adrenergic Muscarinic subtypes M2 and M3 in bladder smooth muscle. M2 80% population, but M3 functionally important Ad...
متن کاملOveractive bladder: pharmacological treatment.
The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize procedures to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and th...
متن کاملCurrent pharmacological and surgical treatment of underactive bladder
187 Abstract Underactive bladder (UAB) or detrusor underactivity (DU) is a common yet still poorly understood urological problem. In addition to true detrusor failure and neuropathy, the inhibitory effects of detrusor contraction by the striated urethral sphincter and the bladder neck through alpha-adrenergic activity may also play a role in the development of UAB or DU. Treatment of UAB or DU ...
متن کاملCurrent pharmacological and surgical treatment of underactive bladder
Underactive bladder (UAB) or detrusor underactivity (DU) is a common yet still poorly understood urological problem. In addition to true detrusor failure and neuropathy, the inhibitory effects of detrusor contraction by the striated urethral sphincter and the bladder neck through alpha-adrenergic activity may also play a role in the development of UAB or DU. Treatment of UAB or DU aims to reduc...
متن کاملOveractive bladder syndrome pharmacotherapy: future treatment options
Overactive bladder syndrome (OAB) is a lifestyle disease and its incidence increases with age. Although it is not a life-threatening disease, it is known to have a significant impact on the quality of life. The first-choice pharmacological treatment of OAB is antimuscarinics. However, their limited clinical effectiveness and unsatisfactory tolerance profile, combined with the advancement of kno...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2016
ISSN: 1742-7835
DOI: 10.1111/bcpt.12577